SLP76 Recombinant Protein (H00003937-P01)(10ug)

Catalog number: H00003937-P01
Price: Ask price from support chat or by Email
Product name: SLP76 Recombinant Protein (H00003937-P01)(10ug)

Applications

WB, ELISA
Uses: Western blot, ELISA. Other unit sizes are available. This protein has not been tested for any functionality. Full length proteins may or may not have enzymatic activity. Any customer feedback on functionality would be greatly appreciated.
Dilutions: ELISA, Western Blot

Background

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq]

Details

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Packaging

Storage: Store at -80C. Avoid freeze-thaw cycles.
Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Unit Size: 10ug (also available: )
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Human

Summary

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Summary:

Teste

WB, ELISA
Uses: Western blot, ELISA. Other unit sizes are available. This protein has not been tested for any functionality. Full length proteins may or may not have enzymatic activity. Any customer feedback on functionality would be greatly appreciated.
Dilutions: ELISA, Western Blot