Integrin beta 3 Antibody (NBP1-43853)(100tests)

Catalog number: NBP1-43853
Price: Ask price from support chat or by Email
Product name: Integrin beta 3 Antibody (NBP1-43853)(100tests)

Applications

FACS
Uses:

This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at 20 μl (0.06 μg)/per test. A test is defined as the amount (μg)/test of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis

Background

The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta3 and GPIIIa. CD61 is a 90-110 kDa member of the /beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alphaIIbbeta3 (CD41/CD61) and alphavbeta3 (CD51/CD61) complexes. Thesealphabeta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.

Details

Immunogen: The immunogen for this antibody was CD61.
Conjugate: PE
Clone: VI-PL2
Isotype: IgG1 Kappa

Notes

Packaging

Storage: Store at 4C. Do not freeze.
Buffer: PBS [pH 7.2]
Preservative: 0.09% Sodium Azide
Unit Size: 100tests (also available: )
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Human
Reactivity: This antibody is reactive to Human..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

FACS
Uses:

This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at 20 μl (0.06 μg)/per test. A test is defined as the amount (μg)/test of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis