CD226 Antibody (NB100-77988)(0.1mg)

Catalog number: NB100-77988
Price: Ask price from support chat or by Email
Product name: CD226 Antibody (NB100-77988)(0.1mg)

Applications

IP, FACS
Uses: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per million cells or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Dilutions: flow cytometry / FACS analysis immunoprecipitation
Conjugated Ab's:
Positive Controls:

Background

CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.

Details

Immunogen: Human cytotoxic T lymphocytes
Clone: DX11
Isotype: IgG1 Kappa

Notes

Packaging

Storage: Store at 4C. Do not freeze.
Buffer: PBS [pH 7.2]
Preservative: 0.09% Sodium Azide
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

  1. Shibuya, A., et al., 1996. Immunity 4(6): 573.
  2. Chen, L., et al., 2003. Life Sci. 73(18): 2373.
  3. Bottino, C., et al., 2003. J. Exp. Med. 198(4): 557.

Species

Primate, Baboon, Human
Reactivity: Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus. .
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

IP, FACS
Uses: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per million cells or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Dilutions: flow cytometry / FACS analysis immunoprecipitation
Conjugated Ab's:
Positive Controls: