TP63 Antibody (NBP1-32326)(0.1ml)

Catalog number: NBP1-32326
Price: Ask price from support chat or by Email
Product name: TP63 Antibody (NBP1-32326)(0.1ml)

Applications

WB
Uses: Western blot. The usefulness of this product in other applications has not been determined.
Dilutions: Western Blot 1:500-1:3000

Background

p63 (also called KET, p51, p40, AIS, and p73L) (1) is a transcription factor that shares a significant amino acid identity with p53 and p73. p63 and p73 can both activate p53-responsive genes and induce apoptosis upon over expression (2). p63 has an additional coding region in the C-termini (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (alpha, beta, and gamma) (3). Additionally, two isoforms can be found; one containing the N-terminal transactivating domain (TA) or the (ÄN) lacking TA (2). p63 plays a more fundamental role associated with development and differentiation. Mutations in p63, although not as common as p53, may result in the ADULT, AEC and ECC3 syndrome (4-5).

Details

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 357 and 630 of Human TP63
Isotype: IgG
Localization: Nucleus

Notes

Packaging

Storage: Store at -20C. Avoid freeze-thaw cycles.
Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0).
Preservative: 0.01% Thimerosal
Concentration: 0.59 mg/ml
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Human
Reactivity: Tested in human. Not yet tested in any other species..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

WB
Uses: Western blot. The usefulness of this product in other applications has not been determined.
Dilutions: Western Blot 1:500-1:3000