IL15RA Antibody (NBP1-43924)(25tests)

Catalog number: NBP1-43924-25tests
Price: Ask price from support chat or by Email
Product name: IL15RA Antibody (NBP1-43924)(25tests)

Applications

FACS
Uses:

This eBioJM7A4 antibody has been pre-titrated and tested by flow cytometric analysis of LPS and IFN-γ-stimulated PBMCs. This can be used at 20 μl (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 �L. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis

Background

The JM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Ralpha). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL2R-beta and -gamma chains, which are essential for signal transduction. The IL-15R-alpha receptor is structurally related to IL-2R-alpha. However, the IL-15Ralpha alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2R-alpha and IL-2. In the human, 3 differentially spliced human IL15R-alpha variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL15R-alpha, like that of IL2R-alpha, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL2R-beta and IL2R-gamma in the absence of the alpha subunit.

Details

Immunogen: The immunogen for this antibody was IL15Ra.
Conjugate: FITC
Clone: JM7A4
Isotype: IgG2b

Notes

Packaging

Storage: Store at 4C. Do not freeze.
Buffer: PBS [pH 7.2] containing BSA and/or gelatin for protein stabilization
Preservative: 0.09% Sodium Azide
Unit Size: 25tests (also available: )
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Human
Reactivity: This antibody is reactive to Human..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

FACS
Uses:

This eBioJM7A4 antibody has been pre-titrated and tested by flow cytometric analysis of LPS and IFN-γ-stimulated PBMCs. This can be used at 20 μl (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 �L. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis