SLP76 Antibody (NBP1-43921)(25tests)

Catalog number: NBP1-43921
Price: Ask price from support chat or by Email
Product name: SLP76 Antibody (NBP1-43921)(25tests)

Applications

FACS
Uses:

This HS76 antibody has been pre-titrated and tested by flow cytometric analysis of fixed and permeabilized normal human peripheral blood mononuclear cells. This can be used at 20 μl (0.5 μg)/per test. A test is defined as the amount (μg)/test of antibody that will stain a cell sample in a final volume of 100 �L. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis

Background

The HS76 antibody reacts with human SLP-76. SLP-76 (SH2 domain-containing leukocyte protein of 76 kD) has also been described as lymphocyte cytosolic protein 2 (LCP2 ) and 76-kDa phosphoprotein (pp76 ). SLP-76 is a cytosolic adaptor protein expressed in several cell types of hematopoietic origin. SLP-76 associates with a number of additional molecules and is required for coupling receptor ligation with more distal signaling events in immature thymocytes, mature T cells, platelets, and mast cells. SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Details

Immunogen: The immunogen for this antibody was SLP76.
Clone: HS76
Isotype: IgG2a

Notes

Packaging

Storage: Store at 4C. Do not freeze.
Buffer: Phosphate buffer pH 7.2,
Preservative: 0.09% Sodium Azide
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Human, Mouse
Reactivity: This antibody is reactive to Mouse, Human..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

FACS
Uses:

This HS76 antibody has been pre-titrated and tested by flow cytometric analysis of fixed and permeabilized normal human peripheral blood mononuclear cells. This can be used at 20 μl (0.5 μg)/per test. A test is defined as the amount (μg)/test of antibody that will stain a cell sample in a final volume of 100 �L. Cell number should be determined empirically but can range from 105 to 108 cells/test.

Dilutions: flow cytometry / FACS analysis