Integrin beta 7 Antibody (NBP1-43538)(0.025mg)

Catalog number: NBP1-43538-0025mg
Price: Ask price from support chat or by Email
Product name: Integrin beta 7 Antibody (NBP1-43538)(0.025mg)

Applications

FACS
Uses:

This FIB504 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Dilutions: flow cytometry / FACS analysis

Background

The FIB504 monoclonal antibody reacts with human and mouse integrin beta7. Integrin beta7 is a 130 kD glycoprotein which associates with integrin alpha4 (CD49d) to form the alpha4beta7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alphaE (CD103) to form the alphaEbeta7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha4beta7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alphaEbeta7 is E-cadherin (CD324). Integrin beta7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.

Details

Immunogen: The immunogen for this antibody was integrin beta7.
Conjugate: Biotin
Clone: FIB504
Isotype: IgG2a Kappa

Notes

Packaging

Storage: Store at 4C. Do not freeze.
Buffer: Aqueous buffer (contains stabilizer if necessary)
Preservative: 0.09% Sodium Azide
Unit Size: 0.025mg (also available: )
Limitations: This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Publications

Species

Mouse, Human
Reactivity: This antibody is reactive to Human, Mouse..
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Summary

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Summary:

Teste

FACS
Uses:

This FIB504 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Dilutions: flow cytometry / FACS analysis